Sodium Hydroxide → HCID 68846281, compound

Participants

Reaction Steps

48 mg 1-(3-phenyl-propylamino)-naphthalene-2-carboxylic acid methyl ester were reacted with 0.14 ml of 2 M sodium hydroxide in 1 ml methanol and 1 ml of THF at 65° C. for 2 h. The organic solvents were then removed in vacuo, and the residue was taken up in water and ethyl acetate. The pH was brought to 3-4 with 2 M hydrochloric acid. The layers were separated and the aqueous layer was extracted with ethyl acetate twice. The combined organic layers were dried over sodium sulphate, and concentrated. After purification by chromatography on silica (ethyl acetate/heptane) 18 mg of 1-(3-phenyl-propylamino)-naphthalene-2-carboxylic acid were obtained.

Provenance & Evidence