HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 68841578, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Methyl 2-aminoisobutyrate hydrochloride | HCID 13258034 | — |
| Reactant | HCID 68846281 | HCID 68846281 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68841578 | HCID 68841578 | 33.2% |
Reaction Steps
Under argon atmosphere 16 mg 1-(3-phenyl-propylamino)-naphthalene-2-carboxylic acid, 10 mg 1-hydroxybenzotriazole, 12 mg 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 18 μl of N,N-diisopropylethylamine in 1 ml of dry DMF were stirred at 0° C. After 30 minutes at 0° C. 8 mg of 2-aminoisobutyric acid methyl ester hydrochloride, followed by 18 μl of N,N-diisopropylethylamine were added. After 16 h at room temperature the reaction mixture was concentrated, and the residue was purified by RP-HPLC to yield 7 mg of 2-methyl-2-{[1-(3-phenyl-propylamino)-naphthalene-2-carbonyl]-amino}-propionic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501981B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-9fb256303be04e39ad1030066e42d82a |
| Source note | uspto-grants-2013_08 |