Ethyl chloroformate → Methyl 2-[(ethoxycarbonyl)amino]-5-ethylthiophene-3-carboxylate

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 2-amino-5-ethylthiophene-3-carboxylate (7.07 g), ethyl chloroformate (4.4 mL) and toluene (100 mL) was stirred at 100° C. for 3 hr. The reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography to give the title compound as colorless oil (9 g, 92%).

Provenance & Evidence