Sodium borohydride → HCID 59351709, compound

Participants

Reaction Steps

To a solution (40 mL) of 4′-{[6-ethyl-3-[2-(2-formyl-1H-imidazol-1-yl)ethyl]-2,4-dioxo-3,4-dihydrothieno[2,3-d]pyrimidin-1(2H)-yl]methyl}biphenyl-2-carbonitrile (2.2 g) in methanol was added sodium borohydride (0.27 g), and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and the residue was extracted with water and ethyl acetate. The obtained ethyl acetate layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound as colorless crystals (2.0 g, 91%).

Provenance & Evidence