1-(Chloromethoxy)-2-methoxyethane → HCID 59351792, compound

Participants

Reaction Steps

To a mixture of 3-(4′-methylbiphenyl-2-yl)-1,2,4-oxadiazol-5(4H)-one (44.1 g), 1-(chloromethoxy)-2-methoxyethane (24 g) and methylene chloride (500 mL) was added a solution (30 mL) of diisopropylethylamine (36.2 mL) in methylene chloride was added, and the mixture was stirred at room temperature for 3 hr. The reaction mixture was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The precipitated solid was collected by filtration to give the title compound as a colorless solid (46.6 g, 78%).

Provenance & Evidence