Potassium Carbonate → HCID 59351773, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-chloropyrimidine-2,4(1H,3H)-dione (10 g), 4′-(bromomethyl)biphenyl-2-carbonitrile (4.71 g), potassium carbonate (27.8 g) and dimethyl sulfoxide (100 mL) was stirred at 65° C. for 2 hr. To the reaction mixture were added 1N aqueous sodium hydroxide solution (70 mL) and toluene (50 mL), and the mixture was cooled to 0° C. The precipitated solid was recrystallized from methanol to give the title compound as colorless crystals (3.3 g, 14%).

Provenance & Evidence