Sodium → HCID 59351601, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 4′-[(6-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]biphenyl-2-carbonitrile (2.3 g) and n-propanol (70 mL) was added a solution of sodium (0.24 g) in n-propanol (10 mL), and the mixture was stirred at 100° C. for 4 hr. The reaction mixture was concentrated under reduced pressure, and the obtained residue was dissolved in water (100 mL). 1N Hydrochloric acid was added to adjust to pH 4, and the precipitated solid was recrystallized from methanol to give the title compound as colorless crystals (1.17 g, 47%).

Provenance & Evidence