Sodium Hydroxide → HCID 136052365, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 5-chloro-2-[6-ethyl-2,4-dioxo-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl]benzoate (0.2 g), 1N aqueous sodium hydroxide solution (10 mL) and tetrahydrofuran (10 mL) was stirred at 100° C. for 2 hr. Tetrahydrofuran was evaporated under reduced pressure, and the residue was adjusted to pH 5 with chloroform and 1N hydrochloric acid, and extracted with chloroform. The obtained chloroform layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The precipitated solid was collected by filtration to give the title compound as colorless crystals (0.13 g, 65%).

Provenance & Evidence