Trifluoroacetic acid → HCID 58531469, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-((3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxyphenylsulfonamido)methyl)-5-(4-fluorophenoxy)benzylcarbamate (0.65 g, 0.96 mmol) in CH2Cl2 (8 mL) was added TFA (1.10 mL, 14.4 mmol). The reaction mixture was stirred at rt. for 3 h. The reaction mixture was concentrated and to the residue was added saturated NaHCO3 solution and ethyl acetate. The organic layer was washed with brine twice, dried over MgSO4, and concentrated in vacuo to give white solid (0.53 g, 96%). 1H NMR (CD3OD): δ 7.49 (d, J=2.8 Hz, 1H), 7.35 (d, J=2.8 Hz, 1H), 7.21-7.09 (m, 4H), 6.99-6.90 (m, 5H), 6.85 (s, 1H), 6.64 (s, 1H), 4.48 (s, 2H), 4.40 (s, 2H), 3.93 (s, 2H); MS (ESI): (M+H)+=579.0.

Provenance & Evidence