4-Biphenylyl isocyanate → HCID 44594823, compound

Participants

Reaction Steps

To a solution of N-(3-(aminomethyl)benzyl)-3,5-dichloro-2-hydroxy-N-(4-(trifluoromethyl)benzyl)benzenesulfonamide (60 mg, 0.12 mmol) in DMF (3 mL) was added 4-biphenyl isocyanate (23.7 mg, 0.12 mmol). The resulting mixture was stirred at rt. for 2 h under nitrogen. The mixture was concentrated and dissolved in MeOH, purified by preparative HPLC. The fractions containing the desired product were combined, concentrated and lyophilized to give white solid (50 mg, 60%).

Provenance & Evidence