Water → HCID 66616501, compound

Participants

Reaction Steps

To a solution of 3-(4-fluorophenoxy)-5-(methoxycarbonyl)benzoic acid (2.2 g, 7.58 mmol) in DMF/CH2Cl2 at rt was added EDCI.HCl (1.889 g, 9.85 mmol) followed by HOBt.H2O (1.024 g, 7.58 mmol) with stirring. After one minute (4-fluorophenyl)methanamine (0.949 g, 7.58 mmol) was added to the mixture and it was stirred at rt for 4 h. EtOAc and aq NaHCO3 were added to the mixture. The EtOAc layer was separated, washed with water, dried over MgSO4 and concentrated in vacuo to obtain a crude product (2.7 g, 6.79 mmol, 90% yield) as a light yellow solid. The crude product was used in the next step without further purification. MS (ESI): (M+H)+=382.21.

Provenance & Evidence