Triethylamine → HCID 86659762, compound

Participants

Reaction Steps

To a solution of 3,5-dichloro-2-hydroxybenzene-1-sulfonyl chloride (27.1 mg, 0.104 mmol) in 4 mL of CH2Cl2 was added solid N-(3-(aminomethyl)-5-(4-fluorophenoxy)benzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide (60 mg, 0.104 mmol) followed by Et3N (110 μL) at rt. The mixture was stirred at rt for 45 min. Direct purification of the reaction mixture by prep HPLC provided the desired product (71 mg, 85%). 1H NMR (CD3OD): δ 7.68 (s, 1H), 7.60 (s, 1H), 7.49 (s, 2H), 7.13˜6.90 (m, 8H), 6.67 (s, 1H), 6.61 (s, 1H), 6.45 (s, 1H), 4.44 (s, 2H), 4.30 (s, 2H), 4.08 (s, 2H); MS (ESI): (M+H)+=805.

Provenance & Evidence