HCID 58531369, compound → HCID 11086076, compound

Participants

Reaction Steps

To a solution of (4′-chloro-2-methoxybiphenyl-3-yl)methanol (800 mg, 3.21 mmol, 1.0 eq) in dry DCM at 0° C. was added pyridinium chlorochromate (3.0 g, 3.91 mmol, 4.3 eq). The reaction mixture was stirred for 1 h, filtered on a silica pad and washed with DCM. The filtrate was evaporated under reduced pressure and the residue was purified by flash column chromatography on silica gel (60-120) eluting with 5-10% ethyl acetate/hexane to afford the desired product (0.430 g, 54%). 1H NMR (400 MHz, CD3OD) δ 3.83-3.94 (s, 3H), 7.02-7.05 (t, 1H), 7.14-7.16 (d, 1H), 7.46-7.48 (t, 1H), 7.57-7.59 (t, 1H), 7.61-7.63 (m, 2H), 7.74-7.76 (d, 1H). MS (ESI): 248.0 (M+H)+.

Provenance & Evidence