1-(4-Bromophenyl)piperidine → HCID 49838267, compound

Participants

Reaction Steps

[8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(4-piperidin-1-yl-phenyl)-amine was prepared from 8-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (100.0 mg, 0.3468 mmol) and 1-(4-bromo-phenyl)-piperidine (110.0 mg, 0.4581 mmol) in a manner analogous to Step 2d. The title compound was isolated as a yellow solid (0.039 g, 25%). MP=229-234° C. 1H NMR (400 MHz, CDCl3, δ, ppm): 8.48-8.45 (m, 1H), 8.25-8.20 (m, 2H), 8.11-8.06 (m, 2H), 7.64-7.61 (m, 1H), 7.49-7.44 (m, 1H), 7.01-6.95 (m, 3H), 6.68 (s, 1H), 3.12-3.07 (m, 7H), 1.77-1.70 (m, 4H), 1.60-1.53 (m, 2H). MS=448 (MH)+.

Provenance & Evidence