Trifluoroacetic acid → HCID 59612378, compound

Participants

Reaction Steps

(2,3-Dihydro-1H-isoindol-5-yl)-[8-(3-methoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-yl]-amine was prepared from 5-[8-(3-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2-ylamino]-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid (0.500 mL) in a manner analogous to Example 312 to give product (0.025 g). MP=95-97° C. 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.68 (s, 1H), 8.80 (d, 1H), 7.85 (d, 1H), 7.80 (s, 1H), 7.70 (m, 2H), 7.52 (m, 1H), 7.45 (m, 1H), 7.18 (d, 1H), 7.10 (t, 1H), 7.00 (d, 1H), 4.10 (br m, 4H), 3.86 (s, 3H), 3.40 (br m, 1H). MS=358 (MH)+.

Provenance & Evidence