2-chloro-N,N-dimethylacetamide → 2-(4-{4-[8-(2,3-Dimethoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperidin-1-yl)-N,N-dimethyl-acetamide

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Reaction Steps

2-(4-{4-[8-(2,3-Dimethoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperidin-1-yl)-N,N-dimethyl-acetamide was prepared from [8-(2,3-dimethoxy-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-yl]-(4-piperidin-4-yl-phenyl)-amine (0.188 g, 0.438 mmol) and 2-chloro-N,N-dimethyl-acetamide (0.067 mL, 0.656 mmol) in a manner analogous to Example 313 to give product (0.050 g, 22%). MP=222-223° C. 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.54 (s, 1H), 8.77 (d, 1H), 7.52 (m, 3H), 7.10 (m, 6H), 3.87 (s, 3H), 3.59 (s, 3H), 3.15 (s, 2H), 3.05 (s, 3H), 2.90 (m, 2H), 2.80 (s, 3H), 2.40 (m, 1H), 2.12 (m, 2H), 1.65 (m, 4H). MS=515 (MH)+.

Provenance & Evidence