4-Aminopyridine → N(8)-(3-Methoxy-benzyl)-N(2)-pyridin-4-yl-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine

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Reaction Steps

N(8)-(3-Methoxy-benzyl)-N(2)-pyridin-4-yl-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine was prepared from (2-chloro-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-(3-methoxy-benzyl)-amine (99.9 mg, 0.346 mmol) and 4-aminopyridine (36.47 mg, 0.3875 mmol) in a manner analogous to Example 2d. Product was isolated as an off-white foam (3.63 mg, 3%). 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 10.02 (s, 1H), 8.32 (m, 2H), 8.00 (d, J=6.7 Hz, 1H), 7.69 (m, 2H), 7.23 (t, J=16.4, 8.2 Hz, 1H), 6.97 (s, 2H), 6.79 (m, 2H), 6.67 (m, 1H), 6.34 (d, J=8.0 Hz, 1H), 4.50 (d, J=6.1 Hz, 2H), 3.72 (s, 3H). MS=347 (MH)+.

Provenance & Evidence