Sodium Thiosulfate → HCID 66707749, compound

Participants

Reaction Steps

To a mixture of 0.30 g of 2,6-dimethyl-5-methylthiomethoxy-4-(2,4,6-triethylphenyl)-3(2H)-pyridazinone [compound (I-2-2)] and 4 mL of dichloromethane, 77 mg of m-chloroperbenzoic acid was added, followed by stirring at room temperature for 30 minutes. To the reaction mixture, an aqueous saturated sodium thiosulfate solution (10 mL) was added, followed by extraction with chloroform (10 mL×2). The organic layers was washed with an aqueous saturated sodium bicarbonate solution (10 mL), dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (ethyl acetate) to obtain 0.16 g of 2,6-dimethyl-5-methylsulfinylmethoxy-4-(2,4,6-triethylphenyl)-3(2H)-pyridazinone [compound (I-3-1)].

Provenance & Evidence