Sodium Thiosulfate → HCID 66707627, compound

Participants

Reaction Steps

To a mixture of 0.30 g of 2,6-dimethyl-5-methylthiomethoxy-4-(2,4,6-triethylphenyl)-3(2H)-pyridazinone [compound (I-2-2)] and 4 mL Of dichloromethane, 205 mg of m-chloroperbenzoic acid was added, followed by stirring at room temperature for 16 hours. To the reaction mixture, an aqueous saturated sodium thiosulfate solution (10 mL) was added, followed by extraction with chloroform (10 mL×2). The organic layer was washed with an aqueous saturated sodium bicarbonate solution (10 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (ethyl acetate:hexane=1:1) to obtain 0.23 g of 2,6-dimethyl-5-methylsulfonylmethoxy-4-(2,4,6-triethylphenyl)-3(2H)-pyridazinone [compound (I-4-1)]. Melting point: 142 to 143° C.

Provenance & Evidence