Sulfuryl chloride → HCID 66707781, compound

HRID 1890223Notes

Reaction equation

HRID 1890223 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2[C:14]([CH2:15][CH3:16])=[CH:13][C:12]([CH2:17][CH3:18])=[CH:11][C:10]=2[CH2:19][CH3:20])=[C:5]([O:21][CH2:22]SC)[C:4]([CH3:25])=[N:3]1.S(Cl)([Cl:29])(=O)=O>C(Cl)(Cl)Cl>[Cl:29][CH2:22][O:21][C:5]1[C:4]([CH3:25])=[N:3][N:2]([CH3:1])[C:7](=[O:8])[C:6]=1[C:9]1[C:14]([CH2:15][CH3:16])=[CH:13][C:12]([CH2:17][CH3:18])=[CH:11][C:10]=1[CH2:19][CH3:20]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 66707556HCID 66707556, compound

Product 1

HCID 66707781HCID 66707781, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a mixture of 0.31 g of 2,6-dimethyl-5-methylthiomethoxy-4-(2,4,6-triethylphenyl)-3(2H)-pyridazinone [compound (I-2-2)] and 3 mL of chloroform, 0.08 mL of sulfuryl chloride was added, followed by stirring under ice cooling for 2.5 hours. The reaction mixture was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (ethyl acetate:hexane=1:4) to obtain 0.14 g of 5-chloromethoxy-2,6-dimethyl-4-(2,4,6-triethylphenyl)-3(2H)-pyridazinone [compound (I-5-1)]. Melting point: 103 to 104° C.

Workup

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ee121e8bc30e4113ad98b09cccbf2169
Source dataset
uspto-grants-2013_08
Patent number
US08507410B2

Reaction notes

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