N-Iodosuccinimide → HCID 67438332, compound

Participants

Reaction Steps

Analogously to Process step [11], 2-[3-(4-fluorophenyl)-1H-pyrazol-5-yl]ethanol can be reacted with 1.1 eq. of NIS in DMF. In a yield of 89%, the desired product is obtained as a mixture of isomers: log P(HCOOH): 1.99; 1H-NMR (DMSO-d6): 13.29 & 13.19 (s, 1H) 7.78 & 7.69 (dd, 2H), 7.38 & 7.28 (dd, 2H), 4.92 & 4.72 (t, 1H), 3.62 (m, 2H), 2.79 & 2.73 (t, 2H).

Provenance & Evidence