HCID 178507773, compound → HCID 178432225, compound

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Reaction Steps

5-Amino-6-(cycloheptylamino)pyridin-2-ol, prepared in a similar manner as the one described in Example 1.3 from 6-(cycloheptylamino)-5-nitropyridin-2-ol, was taken up in trimethylorthoacetate and stirred at room temperature overnight. The solvent was removed under reduced pressure and the residue was purified by preparative HPLC to give the title compound. LCMS m/z=246.1 [M+H]+; 1H NMR (400 MHz, acetonitrile-d3) δ ppm 1.55-1.80 (m, 6H), 1.85-2.05 (m, 4H), 2.50-2.60 (m, 2H), 2.80 (s, 3H), 4.50-4.60 (m, 1H), 6.84 (d, J=8.8 Hz, 1H), 8.01 (d, J=8.8 Hz, 1H).

Provenance & Evidence