Ethanol → HCID 178515771, compound

Participants

Reaction Steps

2,6-Dichloro-3-nitropyridine (0.500 g, 2.59 mmol), 4-aminocyclohexanol (0.298 g, 2.59 mmol), DIEA (1.00 ml, 5.73 mmol) and ethanol (2.0 ml) were heated to 80° C. for 18 h in a sealed flask. The solvent was removed under reduced pressure and the residual solid was purified by preparative HPLC to give the title compound (0.894 g). LCMS m/z=272.2 [M+H]+; 1H NMR (400 MHz, acetonitrile-d3) δ ppm 1.3-1.52 (m, 4H), 2.0-2.1 (m, 2H), 2.15-2.2 (m, 2H), 2.74 (br s, 1H), 6.67 (d, J=8.6 Hz, 1H), 8.16 (br s, 1H), 8.36 (d, J=8.6 Hz, 1H).

Provenance & Evidence