Bromocyclobutane → HCID 178515755, compound

HRID 1890303Notes

Reaction equation

HRID 1890303 reaction equation
C([O:8][C:9]1[N:14]=[C:13]2[NH:15][CH:16]=[N:17][C:12]2=[CH:11][CH:10]=1)C1C=CC=CC=1.Br[CH:19]1[CH2:22][CH2:21][CH2:20]1>>[CH:19]1([N:15]2[C:13]3=[N:14][C:9]([OH:8])=[CH:10][CH:11]=[C:12]3[N:17]=[CH:16]2)[CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 78110BromocyclobutaneHCID 178420377HCID 178420377, compound

Product 1

HCID 178515755HCID 178515755, compound

Procedure

From 5-(benzyloxy)-3H-imidazo[4,5-b]pyridine and bromocyclobutane, prepared in a similar manner as the one described in Example 1.2, the title compound was obtained. LCMS m/z=190.0 [M+H]+; 1H NMR (400 MHz, methanol-d4) δ ppm 2.07 (m, 2H), 2.67 (m, 2H), 2.78 (m, 2H), 5.24 (m, 1H), 6.95 (d, J=8.9 Hz, 1H), 8.08 (d, J=8.9 Hz, 1H), 9.33 (s, 1H).

Sources & evidence

ORD record
ord-9e43706109a442acbbde3902a707248c
Source dataset
uspto-grants-2013_08
Patent number
US08507473B2

Reaction notes

Loading…