Methanesulfonyl chloride → HCID 86655256, compound

Participants

Reaction Steps

5-Nitro-6-(2-(trifluoromethoxy)phenylamino)pyridin-2-ol (1.5 g, 4.8 mmol) was taken up in CH2Cl2 (25 mL). TEA (1.3 ml, 9.5 mmol) was added followed by mesylchloride (0.45 ml, 5.7 mmol). The reaction mixture was stirred at ambient temperature for 1 hour and quenched with 1 N HCl. The layers were separated and the aqueous layer was back extracted with additional CH2Cl2. The combined organic portions were dried over Na2SO4 and concentrated under reduced pressure to give the title compound (1.8 g). 1H NMR (400 MHz, CDCl3) δ ppm 3.26 (s, 3H), 6.54 (d, J=8.8 Hz, 1H), 7.26 (m, 1H), 7.39 (m, 2H), 8.22 (m, 1H), 8.67 (d, J=8.8, 1H), 10.46 (s, 1H).

Provenance & Evidence