Cyclopropanecarboxaldehyde → HCID 178515742, compound

Participants

Reaction Conditions

Reaction Steps

5-Amino-6-(2-(trifluoromethoxy)phenylamino)pyridin-2-ol (0.10 g, 0.32 mmol) was dissolved in nitrobenzene (0.5 mL). Cyclopropanecarbaldehyde (0.044 g, 0.64 mmol) was added. The reaction mixture was heated to 120° C. overnight. After cooling, hexanes was added to the reaction mixture to form a precipitate. The precipitate was collected, washed with hexanes, and purified via HPLC to give the title compound (11 mg). LCMS m/z=336.2 [M+H]+; 1H NMR (400 MHz, methanol-d4) δ ppm 1.35 (m, 4H), 2.03 (m, 1H), 6.86 (d, J=8.8 Hz, 1H), 7.71 (m, 2H), 7.83 (m, 2H), 7.83 (d, J=8.8 Hz, 1H).

Provenance & Evidence