HCID 67312948, compound → HCID 67312934, compound

Participants

Reaction Steps

To a solution of 6-(benzyloxy)-N-(4-ethylphenyl)-3-nitropyridin-2-amine (987 mg, 2.82 mmol in AcOH (6.0 mL) was added zinc dust (737 mg, 11.2 mmol). The mixture was stirred overnight at room temperature, filtered through Celite®, and concentrated. The crude residue was dissolved in EtOAc and washed with saturated NaHCO3. The organics were dried over MgSO4, filtered, and concentrated to give the title compound as a dark brown oil (716 mg). 1H NMR (400 MHz, CDCl3) δ ppm 1.23 (t, J=7.6 Hz, 3H), 2.62 (q, J=7.6 Hz, 2H), 2.95 (broad s, 2H), 5.32 (s, 2H), 6.20 (d, J=8.1 Hz, 1H), 6.65 (broad s, 1H), 7.05 (d, J=8.1 Hz, 1H), 7.11 (d, J=8.4 Hz, 2H), 7.28-7.41 (m, 8H).

Provenance & Evidence