Phosphorus oxybromide → HCID 67312735, compound

Participants

Reaction Steps

A solution of 5-(benzyloxy)-3-(2-fluorophenyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one (244 mg, 0.728 mmol) and POBr3 (2.086 g, 7.28 mmol) in toluene (30 mL) was heated to 100° C. for 72 h in a 40 mL sealed scintillation vial. After cooling to room temperature, the reaction mixture was poured into saturated aqueous NaHCO3 (200 mL) and the mixture was extracted with EtOAc. The organics were washed with brine, dried over MgSO4, filtered, and concentrated to give the title compound (148 mg). LCMS m/z=398.0 [M+H]+.

Provenance & Evidence