反应详情

温度

100 °C

To a solution of 6-chloro-N-cyclohexyl-3-nitropyridin-2-amine (2.16 g, 8.45 mmol) dissolved in dioxane (845 mL) was added 3 M aqueous potassium hydroxide (8.5 mL). The reaction mixture was heated at 100° C. until LCMS showed the starting material was entirely consumed. The reaction mixture was cooled to room temperature and then diluted with water. 1 N HCl was added until the solution turned acidic and a solid was formed. The solid was filtered, washed with water, and dried under vacuum to afford the title compound as a yellow solid (1.58 g). LCMS m/z=238.30 [M+H]+.

1. customwas entirely consumed
2. temperatureThe reaction mixture was cooled to room temperature
3. additiondiluted with water
4. addition1 N HCl was added until the solution
5. customa solid was formed
6. filtrationThe solid was filtered
7. washwashed with water
8. customdried under vacuum