Tert-butyl 3-iodoazetidine-1-carboxylate → 3-(1-benzenesulfonyl-1H-indol-5-yl)azetidine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][C:15](I)=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20]([O:24][C:25]([N:27]1[CH2:30][CH:29](I)[CH2:28]1)=[O:26])([CH3:23])([CH3:22])[CH3:21]>>[C:20]([O:24][C:25]([N:27]1[CH2:30][CH:29]([C:15]2[CH:14]=[C:13]3[C:18](=[CH:17][CH:16]=2)[N:10]([S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:9])=[O:8])[CH:11]=[CH:12]3)[CH2:28]1)=[O:26])([CH3:23])([CH3:21])[CH3:22]Participants
3
Procedure
This compound was prepared from 1-benzenesulfonyl-5-iodo-1H-indole and 3-iodoazetidin-1-carboxylic acid tert-butyl ester by the method outlined under 1.b). ESI-MS [m/z]: 357.05 [M-(C4H9)+H]+.
Sources & evidence
- ORD record
- ord-6d98753d1dfd48119a1a6be6471d35a5
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08507469B2
Reaction notes
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