HCID 24944550, compound → HCID 131730797, compound

HRID 1890370Notes

Reaction equation

HRID 1890370 reaction equation
N1CC(C2C=C3C(=CC=2)N(S(C2C=CC=CC=2)(=O)=O)C=C3)C1.[ClH:23].FC(F)O[C:27]1[CH:32]=[CH:31][C:30]([S:33]([N:36]2[C:44]3[C:39](=[CH:40][C:41]([CH:45]4[CH2:48][N:47]([CH2:49][CH2:50][CH3:51])[CH2:46]4)=[CH:42][CH:43]=3)[CH:38]=[CH:37]2)(=[O:35])=[O:34])=[CH:29][CH:28]=1>>[ClH:23].[C:30]1([S:33]([N:36]2[C:44]3[C:39](=[CH:40][C:41]([CH:45]4[CH2:48][N:47]([CH2:49][CH2:50][CH3:51])[CH2:46]4)=[CH:42][CH:43]=3)[CH:38]=[CH:37]2)(=[O:35])=[O:34])[CH:29]=[CH:28][CH:27]=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 24944550HCID 24944550, compoundHCID 131730798HCID 131730798, compound

Product 1

HCID 131730797HCID 131730797, compound

Procedure

This compound was prepared from 5-azetidin-3-yl-1-(benzensulfonyl)-1H-indole by the method outlined for compound 4. ESI-MS [m/z]: 355.15 [M+H]+. 1H-NMR (500 MHz, d6-DMSO): δ=10.8 (bs, 1H), 7.95 (d, 2H), 7.9 (d, 1H), 7.85 (d, 1H), 7.7 (d, 2H), 7.6 (m, 2H), 7.4 (m, 1H), 6.85 (d, 1H), 4.4 (bs, 2H), 4.3 (bs, 1H), 4.1 (bs, 2H), 3.15 (bs, 2H), 1.55 (m, 2H), 0.95 ppm (t, 3H).

Sources & evidence

ORD record
ord-c5326c8d8fdb47ed9ccb50e12cad66a0
Source dataset
uspto-grants-2013_08
Patent number
US08507469B2

Reaction notes

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