HCID 25074324, compound → HCID 131730799, compound

HRID 1890371Notes

Reaction equation

HRID 1890371 reaction equation
[NH:1]1[CH2:4][CH:3]([C:5]2[CH:6]=[C:7]3[C:11](=[CH:12][CH:13]=2)[N:10]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]4[O:27][CH:26]=[N:25][CH:24]=4)=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH:9]=[CH:8]3)[CH2:2]1.[ClH:28].FC(F)O[C:32]1[CH:37]=CC(S(N2C3C(=CC(C4CN(CCC)C4)=CC=3)C=C2)(=O)=O)=C[CH:33]=1>>[ClH:28].[O:27]1[C:23]([C:20]2[CH:19]=[CH:18][C:17]([S:14]([N:10]3[C:11]4[C:7](=[CH:6][C:5]([CH:3]5[CH2:2][N:1]([CH2:33][CH2:32][CH3:37])[CH2:4]5)=[CH:13][CH:12]=4)[CH:8]=[CH:9]3)(=[O:16])=[O:15])=[CH:22][CH:21]=2)=[CH:24][N:25]=[CH:26]1

Participants

3

Reactant 2

HCID 25074324HCID 25074324, compoundHCID 131730798HCID 131730798, compound

Product 1

HCID 131730799HCID 131730799, compound

Procedure

This compound was prepared from 5-azetidin-3-yl-1-(4-oxazol-5-yl-benzensulfonyl)-1H-indole by the method outlined for compound 4. ESI-MS [m/z]: 422.15 [M+H]+. 1H-NMR (500 MHz, d6-DMSO): δ=10.75 (bs, 1H), 8.55 (s, 1H), 8.1 (d, 2H), 7.9 (m, 5H), 7.7 (s, 1H), 7.4 (m, 1H), 6.85 (d, 1H), 4.4 (m, 2H), 4.25 (m, 1H), 4.1 (m, 2H), 3.15 (m, 2H), 1.55 (m, 2H), 0.95 ppm (t, 3H).

Sources & evidence

ORD record
ord-9eb2fe4436a546339fca03a9f835b5c5
Source dataset
uspto-grants-2013_08
Patent number
US08507469B2

Reaction notes

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