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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1890384Generated: October 25, 2026

3-(Difluoromethoxy)benzenesulfonyl chloride → 3-[1-(3-Difluoromethoxy-benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-yl]-azetidine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/1890384

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Difluoromethoxy)benzenesulfonyl chlorideHCID 2778226—
Reactant3-(1H-Pyrrolo[2,3-b]pyridin-5-yl)-azetidine-1-carboxylic acid tert-butyl esterHCID 68597673—
Product3-[1-(3-Difluoromethoxy-benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-yl]-azetidine-1-carboxylic acid tert-butyl esterHCID 68597699—

Reaction Steps

This compound was prepared from 3-(1H-pyrrolo[2,3-b]pyridine-5-yl)-azetidine-1-carboxylic acid tert-butyl ester and 3-Difluoromethoxy-benzenesulfonyl chloride by the method outlined under Example 46.b.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08507469B2
Source datasetuspto-grants-2013_08
ORD IDord-0efd2dc3bafa4662985386f4983621f9
Source noteuspto-grants-2013_08