Dichloromethane → HCID 67283683, compound

Participants

Reaction Steps

To a solution of 4-(2-trifluoromethyl-pyridin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (4.09 g (11.8 mmol) in dichloromethane (20 mL) is added trifluoroacetic acid (10 mL) and the reaction mixture is stirred at room temperature for one hour. More trifluoroacetic acid (2 mL) is added and stirring is continued for 30 minutes. All volatiles are then removed under high vacuum and to the residue is then added a 4 N solution of HCl in dioxane. All volatiles are then removed again and the residue triturated with diethyl ether. The solid is sucked to dryness and taken up with methanol. After evaporation of all volatiles, the residue is again triturated with diethyl ether and after drying under high vacuum, the desired compound is obtained (26% overall yield).

Provenance & Evidence