tert-Butyl piperazine-1-carboxylate → HCID 86664147, compound

Participants

Reaction Steps

5-Bromo-2-trifluoromethyl-pyridine (1.0 mmol), piperazine-1-carboxylic acid tert-butyl ester (1.2 mmol), sodium tert-butoxide (1.65 mmol), tris-(dibenzylideneacetone)-dipalladium (0.022 mmol) and 2-(dicyclohexylphosphino)-biphenyl (0.064 mmol) are dissolved in dry toluene (5 mL) and the resulting mixture is irradiated in a monomode microwave oven for 30 minutes at 100° C. The reaction is then cooled down to room temperature and ethyl acetate is added (15 mL). The precipitate formed is filtered and the filtrate is concentrated under reduced pressure. The crude product thus obtained is taken up in a minimum volume of dichloromethane (2 mL) and is purified by chromatography over a short silica gel pad (diethyl ether as eluent) to afford the desired product.

Provenance & Evidence