Hydrogen Bromide → HCID 86651033, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.090 g (0.21 mmol) of 9-benzylamino-4-oxo-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-4H-1,4a,7-triaza-benzocycloheptene-7-carboxylic acid ethyl ester dissolved in 3.00 mL of glacial acetic acid was added 0.75 mL (4.28 mmol) of hydrobromic acid (33 wt % solution in glacial acetic acid). The resulting mixture was stirred at 80° C. for 16 hours, cooled and evaporated to dryness. Toluene was added to the residue and evaporated. Ethanol was added to the residue and evaporated. The crude was triturated with diethyl ether and dichloromethane and filtered to afford 0.083 g (76%) of the product as a powder.

Provenance & Evidence