Formaldehyde → HCID 66929836, compound

HRID 1890427Notes

Reaction equation

HRID 1890427 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:12][CH:11]([NH:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[C:10]2=[N:23][C:24]([C:28]3[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=3)=[CH:25][C:26](=[O:27])[N:9]2[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH2:34]=O>>[CH2:1]([O:3][C:4]([N:6]1[CH2:12][CH:11]([N:13]([CH2:14][C:15]2[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=2)[CH3:34])[C:10]2=[N:23][C:24]([C:28]3[CH:29]=[CH:30][N:31]=[CH:32][CH:33]=3)=[CH:25][C:26](=[O:27])[N:9]2[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 86761998HCID 86761998, compound

Product 1

HCID 66929836HCID 66929836, compound

Procedure

By analogy with the method described in example 12 using 9-(4-methoxy-benzylamino)-4-oxo-2-pyridin-4-yl-5,6,8,9-tetrahydro-4H-1,4a,7-triaza-benzocycloheptene-7-carboxylic acid ethyl ester (example 9) in place of 9-amino-4-oxo-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-4H-1,4a,7-triaza-benzocycloheptene-7-carboxylic acid ethyl ester and formaldehyde (37%) in place of benzaldehyde, the compound was obtained as a solid oil. The compound was used as such in the next step.

Workup

  1. customthe compound was obtained as a solid oil

Sources & evidence

ORD record
ord-e869347ec33e4be99e3e5cc2f921d2d7
Source dataset
uspto-grants-2013_08
Patent number
US08507476B2

Reaction notes

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