4-Methoxy-o-phenylenediamine → HCID 136041750, compound

Participants

Reaction Steps

The product is prepared according to the procedure described in Stage 3 of Example 1, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 166 mg of 1,2-diamino-4-methoxybenzene in place of the 1,2-diamino-4-fluorobenzene. After purification by silica gel column chromatography, elution being carried out with a gradient of pure CH2Cl2 to CH2Cl2/MeOH: 85/15, 8 mg of 2-[(6-methoxy-1H-benzimidazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one being obtained in the form of an off-white solid, the characteristics of which are the following:

Provenance & Evidence