p-Toluenesulfonic acid monohydrate → HCID 136041763, compound

Participants

Reaction Steps

The product is prepared according to the procedure described in Example 2, using 316 mg of N-(4-bromo-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide and 73 mg of 4-methylbenzenesulphonic acid hydrate, and replacing the toluene with xylene. After recrystallization from 30 ml of ethanol, 5 ml of methanol and 5 ml of dichloromethane and then purification of the formed precipitate by silica column chromatography, eluent: CH2Cl2/MeOH: 90/10, 70 mg of 2-[(6-bromo-1,3-benzoxazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of an off-white solid, the characteristics of which are the following:

Provenance & Evidence