Acetone → HCID 136041773, compound

Participants

Reaction Steps

The product can be prepared as in stage 1 of Example 11, but using 155 mg of 2-(1H-benzimidazol-2-ylmethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one in 15 ml of acetone, 0.375 ml of sodium hydroxide (2N) and 0.6 ml of iodoethane. After purification by silica column chromatography, eluent: CH2Cl2/MeOH: 95/05, 30 mg of 2-[(1-ethyl-1H-benzimidazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a beige powder, the characteristics of which are the following:

Provenance & Evidence