HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-1,2-diaminobenzene → HCID 136041775, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-1,2-diaminobenzene | HCID 7263 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Sodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate | HCID 136041844 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 136041775 | HCID 136041775 | 49.1% |
Reaction Steps
The product is prepared according to the procedure described in Example 3, using 400 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 436 mg of 4-chlorobenzene-1,2-diamine and 440 mg N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 3.5 ml of pyridine and 3.5 ml of dimethylformamide and then in 7 ml of acetic acid. After refluxing for thirty minutes and purification by silica column chromatography, eluent: CH2Cl2/MeOH: gradient from 100/0 to 90/10, 260 mg of 2-[(6-chloro-1H-benzimidazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white powder, the characteristics of which are the following:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08507483B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-8dabe09c34084996964587c7bd1d7dea |
| Source note | uspto-grants-2013_08 |