2-Aminoresorcinol → HCID 136355298, compound

Participants

Reaction Steps

1.19 g of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 946 mg of 2-aminoresorcinol are added to a solution of 1 g of sodium [4-(morpholin-4-yl)-6-oxo-dihydropyrimidin-2-yl]acetate in 8 ml of pyrimidine. The reaction mixture is stirred at ambient temperature for 18 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 904 mg of N-(2,6-dihydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-acetamide are obtained in the form of a red solid, which is used as it is in the next stage.

Provenance & Evidence