p-Toluenesulfonic acid monohydrate → HCID 136041810, compound

Participants

Reaction Conditions

Reaction Steps

239 mg of 4-methylbenzenesulphonic acid hydrate are added to a solution of 870 mg of N-(2,6-dihydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide in 60 ml of ortho-xylene. The reaction mixture is brought to reflux for 4 hours. After cooling to 0° C., the insoluble material formed is filtered off. The filtrate is concentrated to dryness under reduced pressure and then the residue is chromatographed on a silica gel column, elution being carried out with 90/10 CH2Cl2/MeOH. 654 mg of 2-[(4-hydroxy-1,3-benzoxazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are thus obtained in the form of a white solid, the characteristics of which are the following:

Provenance & Evidence