反应详情

To a solution of 1H-thieno[3,2-c]pyrazole-5-carboxylic acid (G-1) (3.0 g, 17.9 mmol) in MeOH (50 mL) was added concentrated H2SO4 (0.3 mL). The reaction mixture was stirred at reflux for 60 h. Solvent was removed in vacuo. Ethyl acetate was added to dilute the mixture. The mixture was washed with aqueous NaHCO3 solution, dried over Na2SO4, and concentrated in vacuo to afford the title compound (2.4 g).

1. temperatureat reflux for 60 h
2. customSolvent was removed in vacuo
3. additionEthyl acetate was added
4. additionto dilute the mixture
5. washThe mixture was washed with aqueous NaHCO3 solution
6. dry with materialdried over Na2SO4
7. concentrationconcentrated in vacuo