HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromothieno[2,3-b]pyridine → Thieno[2,3-b]pyridine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromothieno[2,3-b]pyridine | HCID 289926 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Thieno[2,3-b]pyridine-3-carbonitrile | HCID 21828305 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
To a stirred solution of 3-bromothieno[2,3-b]pyridine (J-3) (107 mg, 0.5 mmol) and CuCN (60 mg, 0.67 mmol) in anhydrous DMF (4 mL) was added Pd(PPh3)4 (57 mg, 0.05 mmol). The reaction was degassed with nitrogen and stirred at 120° C. for 5 h. Then the cooled mixture was concentrated and purified by chromatography to afford the title compound. MS (m/z): 161 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08507487B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-1dd9ac8032c249518067f2ea150d3289 |
| Source note | uspto-grants-2013_08 |