Ethanol → HCID 67305656, compound

HRID 1890540Notes

Reaction equation

HRID 1890540 reaction equation
[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([C:10]#[N:11])=[CH:2]1.CCO>N.[Ni]>[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH2:10][NH2:11])=[CH:2]1

Participants

5

Reactant 2

HCID 702EthanolHCID 21828305Thieno[2,3-b]pyridine-3-carbonitrile

Product 1

HCID 67305656HCID 67305656, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 222AmmoniaSolvent

Procedure

To a solution of thieno[2,3-b]pyridine-3-carbonitrile (J-4) (320 mg, 2 mmol) in NH3.EtOH (25 mL) was added Ranye/Ni (about 300 mg). The reaction was degassed with hydrogen and stirred at room temperature for 2 h. Then the mixture was filtered, and the filtrate was concentrated to give the title compound, which was used for next step without purification. MS (m/z): 165 (M+1)+.

Workup

  1. customThe reaction was degassed with hydrogen
  2. filtrationThen the mixture was filtered
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-08ab8dbe1b6b4cb7a6b403e1b9d83fa2
Source dataset
uspto-grants-2013_08
Patent number
US08507487B2

Reaction notes

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