Benzothiazole-6-carboxylic acid → 1-(1,3-Benzothiazol-6-yl)ethan-1-amine

HRID 1890559Notes

Reaction equation

HRID 1890559 reaction equation
[S:1]1[C:5]2[CH:6]=[C:7]([CH2:10][NH2:11])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.S1C2C=C(C(O)=O)C=CC=2N=[CH:13]1.Cl.S1C2C=CN=CC=2C=C1CN>>[S:1]1[C:5]2[CH:6]=[C:7]([CH:10]([NH2:11])[CH3:13])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 3

HCID 601670Benzothiazole-6-carboxylic acidHCID 450770136-(Aminomethyl)benzothiazoleHCID 67306703Thieno[3,2-c]pyridin-2-ylmethanamine hydrochloride

Product 1

HCID 673051931-(1,3-Benzothiazol-6-yl)ethan-1-amine

Procedure

Intermediate T′ was prepared from benzo[d]thiazole-6-carboxylic acid (T-1) following similar procedures for synthesizing intermediate D′-5 from D′-1, as described above, and intermediate D from D-4 as described above. MS (m/z): 179 (M+1)+.

Workup

  1. customfor synthesizing intermediate

Sources & evidence

ORD record
ord-ba140772f9544a11bb88fed4665d3ead
Source dataset
uspto-grants-2013_08
Patent number
US08507487B2

Reaction notes

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