Imidazo[1,2-b]pyridazin-6-ylmethanol → Imidazo[1,2-b]pyridazin-6-ylmethanamine

HRID 1890570Notes

Reaction equation

HRID 1890570 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:9]=1[CH:8]=[CH:7][C:6]([CH2:10]O)=[N:5]2.Cl.S1C2C=C[N:18]=CC=2C=C1CN>>[N:1]1[CH:2]=[CH:3][N:4]2[C:9]=1[CH:8]=[CH:7][C:6]([CH2:10][NH2:18])=[N:5]2

Participants

3

Reactant 2

HCID 59580099Imidazo[1,2-b]pyridazin-6-ylmethanolHCID 67306703Thieno[3,2-c]pyridin-2-ylmethanamine hydrochloride

Product 1

HCID 68285393Imidazo[1,2-b]pyridazin-6-ylmethanamine

Procedure

Intermediate 1 was prepared from imidazo[1,2-b]pyridazin-6-ylmethanol (1-4) following the procedures similar to procedure of intermediate D from D-3. MS (m/z): 149 (M+1)+

Sources & evidence

ORD record
ord-ac72ba3b6f974876aa299c3594db591c
Source dataset
uspto-grants-2013_08
Patent number
US08507487B2

Reaction notes

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