反应详情

温度

80 °C

A suspension of methyl 5-acetylpyrazolo[1,5-a]pyridine-3-carboxylate (3-2) (90 mg, 0.41 mmol) dissolved in 50% H2SO4 (2 mL) was stirred at 80° C. for 3 h. After cooled to 0° C., the solution was treated with 5N NaOH solution, and then extracted with Et2O. The organic layer was separated, dried, concentrated and purified by flash chromatography to afford the title compound (25 mg).

1. temperatureAfter cooled to 0° C.
2. extractionextracted with Et2O
3. customThe organic layer was separated
4. customdried
5. concentrationconcentrated
6. custompurified by flash chromatography