7-(Azidomethyl)[1,2,4]triazolo[1,5-a]pyridine → HCID 68288052, compound

HRID 1890578Notes

Reaction equation

HRID 1890578 reaction equation
[N:1]([CH2:4][C:5]1[CH:10]=[CH:9][N:8]2[N:11]=[CH:12][N:13]=[C:7]2[CH:6]=1)=[N+]=[N-]>CO.[Pd]>[N:13]1[CH:12]=[N:11][N:8]2[CH:9]=[CH:10][C:5]([CH2:4][NH2:1])=[CH:6][C:7]=12

Participants

4

Reactant 1

HCID 866714377-(Azidomethyl)[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 68288052HCID 68288052, compoundYield 106.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 7-(azidomethyl)-[1,2,4]triazolo[1,5-a]pyridine (4-4) (340 mg, 1.9 mmol) in methanol (20 mL) was added Pd/C (30 mg). The reaction mixture was stirred at room temperature under H2 (1 atm) for 2 h. The mixture was filtered to remove Pd/C. The filtrate was concentrated to afford the title compound (300 mg) MS (m/z): 149 (M+1)+.

Workup

  1. filtrationThe mixture was filtered
  2. customto remove Pd/C
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-04a60975b06943d6ac5c423ab88ad90e
Source dataset
uspto-grants-2013_08
Patent number
US08507487B2

Reaction notes

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